Coding

Part:BBa_K5477020:Design

Designed by: Kate Malana Escobar   Group: iGEM24_UCopenhagen   (2024-09-26)


CYP3A4 - Cytochrome P450 3A4 codon-optimized for Saccharomyces cerevisiae


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal XbaI site found at 1483
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal XbaI site found at 1483
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal XbaI site found at 1483
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

In the context of our system, CYP3A4 is integrated into a detoxification module where it initiates the oxidative breakdown of toxic compounds, such as pharmaceuticals and environmental pollutants, allowing these substances to be further processed and excreted. The inclusion of CYP3A4 in our detox module provides a broad-spectrum solution for metabolizing diverse toxins and drugs.



Source

Homo sapiens

References